06 Abr. 2022

Highlighting the lack of neuropsychologists and speech therapists in healthcare services towards an accurate (pre- and postoperative) cognitive assessment in low-grade glioma patients

Low-grade gliomas (LGGs) are a slow-growth type of brain tumor usually located in the vicinity of areas that are essential for a wide range of cognitive processes including language, memory, or movement, causing disruptions on the patient's daily activities. With all due risks considered, resection is the usual treatment for ...

14 Ene. 2022

Oscillatory dynamics underlying noun and verb production in highly proficient bilinguals

Words representing objects (nouns) and words representing actions (verbs) are essential components of speech across languages. While there is evidence regarding the organizational principles governing neural representation of nouns and verbs in monolingual speakers, little is known about how this knowledge is represented in the bilingual brain. To address this ...

15 Abr. 2021

Oscillatory and structural signatures of language plasticity in brain tumor patients: A longitudinal study

Recent evidence suggests that damage to the language network triggers its functional reorganization. Yet, the spectro-temporal fingerprints of this plastic rearrangement and its relation to anatomical changes is less well understood. Here, we combined magnetoencephalographic recordings with a proxy measure of white matter to investigate oscillatory activity supporting language plasticity ...

05 Abr. 2021

MULTIMAP: Multilingual picture naming test for mapping eloquent areas during awake surgeries. Behav Res Methods

Picture naming tasks are currently the gold standard for identifying and preserving language-related areas during awake brain surgery. With multilingual populations increasing worldwide, patients frequently need to be tested in more than one language. There is still no reliable testing instrument, as the available batteries have been developed for specific ...

26 Mar. 2021

What Can Glioma Patients Teach Us about Language (Re)Organization in the Bilingual Brain: Evidence from fMRI and MEG

Recent evidence suggests that the presence of brain tumors (e.g., low-grade gliomas) triggers language reorganization. Neuroplasticity mechanisms called into play can transfer linguistic functions from damaged to healthy areas unaffected by the tumor. This phenomenon has been reported in monolingual patients, but much less is known about the neuroplasticity of ...

23 Feb. 2021

Use and impact of high intensity treatments in patients with traumatic brain injury across Europe: a CENTER-TBI analysis

Purpose: To study variation in, and clinical impact of high Therapy Intensity Level (TIL) treatments for elevated intracranial pressure (ICP) in patients with traumatic brain injury (TBI) across European Intensive Care Units (ICUs). Methods: We studied high TIL treatments (metabolic suppression, hypothermia (< 35 °C), intensive hyperventilation (PaCO2 < 4 kPa), ...

02 Dic. 2020

Understanding the relationship between cognitive performance and function in daily life after traumatic brain injury

Objective: Cognitive impairment is a key cause of disability after traumatic brain injury (TBI) but relationships with overall functioning in daily life are often modest. The aim is to examine cognition at different levels of function and identify domains associated with disability. Methods: 1554 patients with mild-to-severe TBI were assessed at ...

15 Sep. 2020

A Practical Approach to Imaging of the Supplementary Motor Area and Its Subcortical Connections

Purpose of review: First, an anatomical and functional review of these cortical areas and subcortical connections with T-fMRI and tractography techniques; second, to demonstrate the value of this approach in neurosurgical planning in a series of patients with tumors close to the SMA. Recent findings: Implications in language and cognitive networks ...

15 Mar. 2020

Spatiotemporal dynamics of postoperative functional plasticity in patients with brain tumors in language areas

Postoperative functional neuroimaging provides a unique opportunity to investigate the neural mechanisms that facilitate language network reorganization. Previous studies in patients with low grade gliomas (LGGs) in language areas suggest that postoperative recovery is likely due to functional neuroplasticity in peritumoral and contra-tumoral healthy regions, but have attributed varying degrees ...

10 Ago. 2018

Neural correlates of phonological, orthographic and semantic reading processing in dyslexia

Developmental dyslexia is one of the most prevalent learning disabilities, thought to be associated with dysfunction in the neural systems underlying typical reading acquisition. Neuroimaging research has shown that readers with dyslexia exhibit regional hypoactivation in left hemisphere reading nodes, relative to control counterparts. This evidence, however, comes from studies ...